In addition to the above indirect measurements of adrenocortical activation, tests were conducted on the capacity of pantothenic acid-depleted rats to survive following egg white intoxication (the latter has been employed as a functional test for the presence of cortisone-like hormones in the rat). Findings for pantothenic acid-depleted rats were contrasted to those observed for rats fed a complete ration, either ad libitum or in an amount equal to that ingested daily by rats on the pantothenate-free ration. Pituitary-adrenal activation following epinephrine and ACTH administration was measured by the following indices of adrenocortical activation: (1) reduction in the peripheral lymphocyte count (2) adrenal ascorbic acid depletion and (3) reduction in adrenal cholesterol concentration. Tests were conducted to determine the effects of pantothenic acid deficiency on the pituitary-adrenal system of the rat.
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